Features
of this disease that we know clearly imbalance chromosomal only lead to
the emergence of this disease is a exchange of two pieces of each of
the chromosome 9 and 22 which give rise to chromosome called Krromuzum
Philadelphia and lead to loss of cells characteristic programmed death
and thus to a proliferation of cells white
blood without limits with no loss of property excellence, and show that
these cells form a natural, though very large numbers in the bone
marrow and blood as well as in the collapse of the barrier between the
bone marrow and blood.
But, as we mentioned earlier, there are a limited area of the spinal marrow and that the proliferation of white blood cells, strong lead to poor production of red blood cells and in most cases, get there an increase in blood platelets, cells that produce them as well get this disease, the emergence of the production of blood outside the bone marrow is usually in the spleen and liver failure and liver function at least in part. The proliferation of these cells leads to a large consumption of energy for the body in the production of these cells and lead to an increased so-called feces metabolism, causing some symptoms of the disease.
Symptoms of chronic myeloid leukemiaSome patients may have no symptoms for a long time, and discovers they have the disease by chance when an analysis of the blood, we find a proliferation of white blood cells and when conducting further tests to reach this diagnosis. There are other patients there have some mild symptoms such as symptoms of anemia (weakness, fatigue, headache, palpitation heart, shortness of breath when you exert effort), there have symptoms due to an enlarged spleen or liver, leading to poor digestion and a feeling of fullness when eating a small amount of food . Some other patients appear to have tumors in the different members of the body as a result the production of bone marrow outside the natural places.
Diagnosis of chronic myeloid leukemiaGiven above is sick with a proliferation of white blood cell count and neutrophil-forming cells have a strong suspicion the existence of the disease. Be sure of the diagnosis examinations chemical on the cells, and chromosomal tests to detect the presence of the Philadelphia chromosome, which is certainly the diagnosis.
Treatment of chronic myeloid leukemiaCan control the symptoms of this disease and to produce cells Almtcather by drugs, chemicals given by mouth as easily as drug hydroxyurea Hydroxyurea but it gets the disease after a period continue at the rate of 3-5 years is transmitted to the process of the most virulent resembles acute leukemia and is less responsive for treatment of acute leukemia that is not preceded by a blood cancer chronic spinal and when it is difficult to control this disease usually leads to death.
During the eighties of the twentieth century, discovered that giving injectable interferon subcutaneous doses sufficient happens disappearance of the Philadelphia chromosome that causes the disease, raising great hopes to get rid of this disease once and for all as possible, and then in about the same time studies have shown that a transplant of bone marrow in the early stages of the disease also occur disappearance of the disease once and for all and the disappearance of the chromosome that causes the disease called Pkromuzum Philadelphia and the difference is that giving drugs interferon for a long number of years followed by a return of the disease in most cases after stopping this treatment, although some patients remain free of disease, almost always, while patients who who underwent bone marrow transplant rid of this disease for good.
Bone Marrow Transplantation of course this process is not easy and is associated with a mortality rate of between 15-20% in most centers, with the proportion of the world suffering from the symptoms of different diseases up to 40-50% while giving the injection of interferon cause some side effects during the treatment period, but can get rid of this symptoms after stopping treatment or by giving other drugs such as Mahbtat heat and antibiotics. On the other side as we have said in most cases because the disease again when you stop treatment because of that that in spite of the disappearance of chromosome called Pkromuzum Philadelphia but the genetic defect can be detected in most of these cases by testing DNA, which demonstrates that the genetic defect still exists, although of interferon treatment.
It remains to say that during the year 2000-2001 was announced the discovery of a new drug by mouth gives the latest jolt in the media and the public when he became the talk is about to get rid of this disease once and without the need for Bone Marrow Transplantation and the drug is a drug given by mouth called Gelevk Gleevec The drug is a drug inhibits the enzyme active resulting from the Philadelphia chromosome, but it was too early to say that this drug actually eliminate the disease completely, because tests of molecular DNA in cases of patients who responded to treatment and those who disappeared have the features of the disease and disappeared chromosome that causes the disease called Philadelphia chromosome showed that the imbalance gene still exists in most cases, however, that due to the success of this treatment significantly to the elimination of imbalance molecular disease of the enzyme active resulting from the Philadelphia chromosome, we can say that this drug has led to the postponement of the decision-making cultivation of bone marrow has become indispensable for good in this disease.
But, as we mentioned earlier, there are a limited area of the spinal marrow and that the proliferation of white blood cells, strong lead to poor production of red blood cells and in most cases, get there an increase in blood platelets, cells that produce them as well get this disease, the emergence of the production of blood outside the bone marrow is usually in the spleen and liver failure and liver function at least in part. The proliferation of these cells leads to a large consumption of energy for the body in the production of these cells and lead to an increased so-called feces metabolism, causing some symptoms of the disease.
Symptoms of chronic myeloid leukemiaSome patients may have no symptoms for a long time, and discovers they have the disease by chance when an analysis of the blood, we find a proliferation of white blood cells and when conducting further tests to reach this diagnosis. There are other patients there have some mild symptoms such as symptoms of anemia (weakness, fatigue, headache, palpitation heart, shortness of breath when you exert effort), there have symptoms due to an enlarged spleen or liver, leading to poor digestion and a feeling of fullness when eating a small amount of food . Some other patients appear to have tumors in the different members of the body as a result the production of bone marrow outside the natural places.
Diagnosis of chronic myeloid leukemiaGiven above is sick with a proliferation of white blood cell count and neutrophil-forming cells have a strong suspicion the existence of the disease. Be sure of the diagnosis examinations chemical on the cells, and chromosomal tests to detect the presence of the Philadelphia chromosome, which is certainly the diagnosis.
Treatment of chronic myeloid leukemiaCan control the symptoms of this disease and to produce cells Almtcather by drugs, chemicals given by mouth as easily as drug hydroxyurea Hydroxyurea but it gets the disease after a period continue at the rate of 3-5 years is transmitted to the process of the most virulent resembles acute leukemia and is less responsive for treatment of acute leukemia that is not preceded by a blood cancer chronic spinal and when it is difficult to control this disease usually leads to death.
During the eighties of the twentieth century, discovered that giving injectable interferon subcutaneous doses sufficient happens disappearance of the Philadelphia chromosome that causes the disease, raising great hopes to get rid of this disease once and for all as possible, and then in about the same time studies have shown that a transplant of bone marrow in the early stages of the disease also occur disappearance of the disease once and for all and the disappearance of the chromosome that causes the disease called Pkromuzum Philadelphia and the difference is that giving drugs interferon for a long number of years followed by a return of the disease in most cases after stopping this treatment, although some patients remain free of disease, almost always, while patients who who underwent bone marrow transplant rid of this disease for good.
Bone Marrow Transplantation of course this process is not easy and is associated with a mortality rate of between 15-20% in most centers, with the proportion of the world suffering from the symptoms of different diseases up to 40-50% while giving the injection of interferon cause some side effects during the treatment period, but can get rid of this symptoms after stopping treatment or by giving other drugs such as Mahbtat heat and antibiotics. On the other side as we have said in most cases because the disease again when you stop treatment because of that that in spite of the disappearance of chromosome called Pkromuzum Philadelphia but the genetic defect can be detected in most of these cases by testing DNA, which demonstrates that the genetic defect still exists, although of interferon treatment.
It remains to say that during the year 2000-2001 was announced the discovery of a new drug by mouth gives the latest jolt in the media and the public when he became the talk is about to get rid of this disease once and without the need for Bone Marrow Transplantation and the drug is a drug given by mouth called Gelevk Gleevec The drug is a drug inhibits the enzyme active resulting from the Philadelphia chromosome, but it was too early to say that this drug actually eliminate the disease completely, because tests of molecular DNA in cases of patients who responded to treatment and those who disappeared have the features of the disease and disappeared chromosome that causes the disease called Philadelphia chromosome showed that the imbalance gene still exists in most cases, however, that due to the success of this treatment significantly to the elimination of imbalance molecular disease of the enzyme active resulting from the Philadelphia chromosome, we can say that this drug has led to the postponement of the decision-making cultivation of bone marrow has become indispensable for good in this disease.
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