Frequently
the disease in adults and in children less than in this disease
proliferate primitive cells Primitive cells are similar to the mother
until it fills most of the bone marrow so that it does not remain only a
limited area to normal cells, the symptoms, he spoke of so-called
failure of the bone marrow.
This disease has several sub-types were distinguished according to the form of cells and normal cells according to their origins. Then in the last period of the disease has become divided by imbalances in chromosomes which can be detected with laboratory-proven to be some cases where there are imbalances in certain chromosomes (16, 15-17 or 8-21) where the disease is less serious than other cases in the chromosomes (5 or 7).
Symptoms of acute myeloid leukemiaThe symptoms of acute myeloid leukemia is usually not specific to this disease alone, for example, the patient feels weak in dizziness and fatigue and shortness of breath upon exertion and palpitations heart has been inclined to bleeding from the gums or nose was showing the effects of bleeding under the skin in the form of rash in the legs or patches blood in different parts of the body temperature may rise has the presence of bacterial infection in the place of the body or the public in the blood, and called these symptoms are symptoms of bone marrow failure, because the weakness caused by the production of red blood cells, white and platelets.
Diagnosis of acute myeloid leukemiaBecause the symptoms of this disease is not his own alone, so it must be for a doctor to have a high degree of uncertainty in this disease, especially if symptoms met twice the production of more than one type of blood cell.
In a study published by me in the medical blogging Saudi Arabia showed that all patients who Ainthm during 1993-1994 AD had access to the suspected diagnosis by a very simple analysis of a number of blood cells, and examination of a slice of blood under the microscope. Therefore it is necessary to make this simple analysis for the largest number of patients who have the symptoms mentioned, and must be a suspicion and refer the patient to a specialized center in the treatment of these diseases to rule out this suspicion. Usually the diagnosis is confirmed by the bone marrow to make which is a simple procedure done under local anesthesia or after the hypnotic injection and does not require general anesthesia except when the examination in children. Then if you are sure of the disease are special tests to make sure of the exact type of the patient and checks chromosomes to consider the possibility of response to treatment.
Treatment of acute myeloid leukemiaThe treatment of the disease through intensive chemotherapy, which lasts for 5-10 days using 2-3 drugs, often involving drug Cytarabine and one in the group of drugs such as Anthracycline drug Daunorubicine.
Unfortunately, all drugs effective in this disease attacking the normal cells of the bone marrow such as the attack disease cells malignant and therefore increase the symptoms of bone marrow failure for a temporary period goes three to four weeks after the treatment period mentioned, then restores the bone marrow recover and return blood cells to normal reproduction, growth and return production the blood and symptoms disappear, bone marrow failure in question.
The reason is that normal cells due to its activity and reproduction without the return of malignant cells to malignant cells proliferate at a slower rate than normal cells in this disease, but there is an imbalance in the malignant cells prevents them from excellence to cells capable of performing the functions assigned to it, as well as among these cells lack for access to the so-called programmed death Apoptosis thus increasing their number in the bone without the high speed reproduction.
Due to the increasing severity of the symptoms of bone marrow failure and the weakness of the cells in the period following the treatment the patient needs during this period to isolate the reverse, so you must be in a single room alone is not included by the person, whether from hospital staff or visitors only after taking precautions such as washing hands and wearing a muzzle on the mouth , nose, and if there is a rise in temperature are sent samples of farm to blood and other to the laboratory and then begins to give the patient antibiotics powerful and effective in high doses intravenously without waiting for proof of an infection in the patient, and are reviewed antibiotics prescribed to the patient every 3 days and compared the situation of the patient as well as compare the results of samples sent to the laboratory farm has added new antibiotics or replace antibiotics described previously.
As well as the patient needs a blood transfusion (red blood cells) and the transfer of platelets, and where the patient needs to repeat the transfer of blood and platelets usually, so it is used in these cases the so-called preparations of blood filtered to prevent the transfer of white blood cells to the patient as these white blood cells cause formation of antibodies againstHLA tissue characteristics, which could lead to the destruction of platelets, which will be transferred Antigens in the future and other immune problems.
The platelets, there are two types of platelets, the first type is the one who attends by separating whole blood units that are donated to the products such as red blood cell concentrates, plasma, platelets. And units of platelets, these are called scientifically plasma with a high content of platelets Platelet Rich Plasma and each of these units contains thirty billion of platelets only, and this quantity is not complete to find a convenient height in the concentration of platelets in the recipients of these plates, so it had to be collection units 6-8 and from 6-8 different people each donated unit of whole blood. If we had to 6-8 and other units of 6-8 other people at a time where the patient needs to platelets, because people who have donated unit of blood full can not donate again until after 3 months, we can imagine that the patient will receive blood products from dozens or even hundreds of persons during treatment.
The second type of blood platelets to attend by a device called a separation of cells is connected to the donor and then run a special program in a computer device to separate the platelets are passing blood donated through the tube passes into the device (which is similar to dialysis) and then by a special technique is separated platelets and collecting in a special bag and return all other blood components such as red blood cells and plasma to the donor. Every unit of this type are similar 6-8 and units of the first type and therefore expose the patient who needs to transfer plates to blood from a single donor, but can someone donated platelets by this technique to donate platelets again in two or three, when the patient visits Others in need of platelets and thus limit the number of people who move their products to the patient's blood to a number much less than if we used platelets from the first type.
Here we get two benefits, first advantage is the possibility of prevention of infection as it is known that the transfer of blood or any of the Msthoudrath remain viable for the transfer of serious viral diseases such as hepatitis or AIDS virus types. Although the conduct of all necessary tests to make sure of his safety, but this possibility is very small up to 1 of 60,000 in the case of hepatitis B or to 1 than 500000 in the case of HIV, as demonstrated by research in the United States. Therefore, when we transfer the patient's sheets from a single donor repeatedly during the 3 months are likely to infect much lower than the probability of transmission in case of transfer of sheets from more than two hundred donated within three months and a second advantage to exposing the patient of platelets from a donor who is of course different from the patient features in HLA-Antigens tissue leads to the possible formation of antibodies of the characteristics of this tissue, and of course be a possibility in the case of the patient's exposure to platelets from a single donor, as is the case if the transfer to plates from a single donor by a separation of the cells.
After the stage of intensive treatment of these and the subsequent period of weak blood cells, which must be overcome as we fight against bacterial infections and the transfer of red blood cells and the transfer of blood platelets, and restores the bone marrow recover and begin producing normal blood cells do not find any trace of malignant cells in the event of response to treatment, but that despite this success, we know that there are many patients there are still malignant cells in the bone marrow they have and because of that malignant cells resemble cells mother natural and therefore can not distinguish if they are present at less than 5% of the bone marrow Therefore, we re-cycle or more of the chemotherapy intensive to try to ensure that the return of the disease and are these courses combined again a period of weakness for the blood cells that are twice the resistance of bacterial infections and the need to move the red blood cells and the transfer of blood platelets, and then the return of normal cells again.
Until recently, all patients with acute myeloid leukemia are advised to make the process of cultivation of bone marrow, but today we know that there is a group of patients who could return the disease to them exist but are so small that it does not warrant a bone marrow transplant at least now because the process of cultivation the bone marrow itself take the risk is considerable.
This disease has several sub-types were distinguished according to the form of cells and normal cells according to their origins. Then in the last period of the disease has become divided by imbalances in chromosomes which can be detected with laboratory-proven to be some cases where there are imbalances in certain chromosomes (16, 15-17 or 8-21) where the disease is less serious than other cases in the chromosomes (5 or 7).
Symptoms of acute myeloid leukemiaThe symptoms of acute myeloid leukemia is usually not specific to this disease alone, for example, the patient feels weak in dizziness and fatigue and shortness of breath upon exertion and palpitations heart has been inclined to bleeding from the gums or nose was showing the effects of bleeding under the skin in the form of rash in the legs or patches blood in different parts of the body temperature may rise has the presence of bacterial infection in the place of the body or the public in the blood, and called these symptoms are symptoms of bone marrow failure, because the weakness caused by the production of red blood cells, white and platelets.
Diagnosis of acute myeloid leukemiaBecause the symptoms of this disease is not his own alone, so it must be for a doctor to have a high degree of uncertainty in this disease, especially if symptoms met twice the production of more than one type of blood cell.
In a study published by me in the medical blogging Saudi Arabia showed that all patients who Ainthm during 1993-1994 AD had access to the suspected diagnosis by a very simple analysis of a number of blood cells, and examination of a slice of blood under the microscope. Therefore it is necessary to make this simple analysis for the largest number of patients who have the symptoms mentioned, and must be a suspicion and refer the patient to a specialized center in the treatment of these diseases to rule out this suspicion. Usually the diagnosis is confirmed by the bone marrow to make which is a simple procedure done under local anesthesia or after the hypnotic injection and does not require general anesthesia except when the examination in children. Then if you are sure of the disease are special tests to make sure of the exact type of the patient and checks chromosomes to consider the possibility of response to treatment.
Treatment of acute myeloid leukemiaThe treatment of the disease through intensive chemotherapy, which lasts for 5-10 days using 2-3 drugs, often involving drug Cytarabine and one in the group of drugs such as Anthracycline drug Daunorubicine.
Unfortunately, all drugs effective in this disease attacking the normal cells of the bone marrow such as the attack disease cells malignant and therefore increase the symptoms of bone marrow failure for a temporary period goes three to four weeks after the treatment period mentioned, then restores the bone marrow recover and return blood cells to normal reproduction, growth and return production the blood and symptoms disappear, bone marrow failure in question.
The reason is that normal cells due to its activity and reproduction without the return of malignant cells to malignant cells proliferate at a slower rate than normal cells in this disease, but there is an imbalance in the malignant cells prevents them from excellence to cells capable of performing the functions assigned to it, as well as among these cells lack for access to the so-called programmed death Apoptosis thus increasing their number in the bone without the high speed reproduction.
Due to the increasing severity of the symptoms of bone marrow failure and the weakness of the cells in the period following the treatment the patient needs during this period to isolate the reverse, so you must be in a single room alone is not included by the person, whether from hospital staff or visitors only after taking precautions such as washing hands and wearing a muzzle on the mouth , nose, and if there is a rise in temperature are sent samples of farm to blood and other to the laboratory and then begins to give the patient antibiotics powerful and effective in high doses intravenously without waiting for proof of an infection in the patient, and are reviewed antibiotics prescribed to the patient every 3 days and compared the situation of the patient as well as compare the results of samples sent to the laboratory farm has added new antibiotics or replace antibiotics described previously.
As well as the patient needs a blood transfusion (red blood cells) and the transfer of platelets, and where the patient needs to repeat the transfer of blood and platelets usually, so it is used in these cases the so-called preparations of blood filtered to prevent the transfer of white blood cells to the patient as these white blood cells cause formation of antibodies againstHLA tissue characteristics, which could lead to the destruction of platelets, which will be transferred Antigens in the future and other immune problems.
The platelets, there are two types of platelets, the first type is the one who attends by separating whole blood units that are donated to the products such as red blood cell concentrates, plasma, platelets. And units of platelets, these are called scientifically plasma with a high content of platelets Platelet Rich Plasma and each of these units contains thirty billion of platelets only, and this quantity is not complete to find a convenient height in the concentration of platelets in the recipients of these plates, so it had to be collection units 6-8 and from 6-8 different people each donated unit of whole blood. If we had to 6-8 and other units of 6-8 other people at a time where the patient needs to platelets, because people who have donated unit of blood full can not donate again until after 3 months, we can imagine that the patient will receive blood products from dozens or even hundreds of persons during treatment.
The second type of blood platelets to attend by a device called a separation of cells is connected to the donor and then run a special program in a computer device to separate the platelets are passing blood donated through the tube passes into the device (which is similar to dialysis) and then by a special technique is separated platelets and collecting in a special bag and return all other blood components such as red blood cells and plasma to the donor. Every unit of this type are similar 6-8 and units of the first type and therefore expose the patient who needs to transfer plates to blood from a single donor, but can someone donated platelets by this technique to donate platelets again in two or three, when the patient visits Others in need of platelets and thus limit the number of people who move their products to the patient's blood to a number much less than if we used platelets from the first type.
Here we get two benefits, first advantage is the possibility of prevention of infection as it is known that the transfer of blood or any of the Msthoudrath remain viable for the transfer of serious viral diseases such as hepatitis or AIDS virus types. Although the conduct of all necessary tests to make sure of his safety, but this possibility is very small up to 1 of 60,000 in the case of hepatitis B or to 1 than 500000 in the case of HIV, as demonstrated by research in the United States. Therefore, when we transfer the patient's sheets from a single donor repeatedly during the 3 months are likely to infect much lower than the probability of transmission in case of transfer of sheets from more than two hundred donated within three months and a second advantage to exposing the patient of platelets from a donor who is of course different from the patient features in HLA-Antigens tissue leads to the possible formation of antibodies of the characteristics of this tissue, and of course be a possibility in the case of the patient's exposure to platelets from a single donor, as is the case if the transfer to plates from a single donor by a separation of the cells.
After the stage of intensive treatment of these and the subsequent period of weak blood cells, which must be overcome as we fight against bacterial infections and the transfer of red blood cells and the transfer of blood platelets, and restores the bone marrow recover and begin producing normal blood cells do not find any trace of malignant cells in the event of response to treatment, but that despite this success, we know that there are many patients there are still malignant cells in the bone marrow they have and because of that malignant cells resemble cells mother natural and therefore can not distinguish if they are present at less than 5% of the bone marrow Therefore, we re-cycle or more of the chemotherapy intensive to try to ensure that the return of the disease and are these courses combined again a period of weakness for the blood cells that are twice the resistance of bacterial infections and the need to move the red blood cells and the transfer of blood platelets, and then the return of normal cells again.
Until recently, all patients with acute myeloid leukemia are advised to make the process of cultivation of bone marrow, but today we know that there is a group of patients who could return the disease to them exist but are so small that it does not warrant a bone marrow transplant at least now because the process of cultivation the bone marrow itself take the risk is considerable.
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