Systemic
lupus erythematosus Systemic Lupus Erythematosus or SLE is a disease of
autoimmune autoimmune diseases, which is part of a group of diseases
attacking the immune system tissues and cells of the body causing the
inflammation and damage which is a flaw and that's where the essential
function of the functions of the immune system is to identify what is strange
and hostile to our bodies - such as microbes, viruses or harmful
material - and what is in the structure of our body cells and tissues
and organs.
A chronic disease that affects multiple organ multisystem, and is characterized by the existence of periods of activity, exacerbations and periods of latency remissions, and most of the injuries it is among women aged 15 to 45 years ie in the period fertility child bearing age, where the ratio between them from 70 to 90 percent of the total injuries disease, and disease can affect all ages, including newborn neonates.
PathophysiologyEstablished disease as a result response is normal or abnormal environmental factors (such as exposure to UV ultra-violet rays - and contained within the rays of the sun and in the light rays emitted from the light industrial - and such as exposure to infection, or taking certain medications) in people who have a genetic predisposition, As a result of this response consists of antibodies autoimmune diseases attack the body's tissues and inflammation occur by inflamation or damage to vehicles and damage immune immune complexes are deposited in blood vessels and organs of the body.
Symptoms and signsSince the disease affects multiple body organs, the symptoms and signs are numerous and vary from case to case, including:
Symptoms and signs of disease prevalent
It is joint pain and inflammation arthralgias and arthritis, and rash face and skin malar and other skin rashes and inflammation of the membranes around the lungs, heart, pleuritis or pericarditis also include the incidence of kidney and central nervous system renal and CNS involvement, as well as a decrease in the number of blood cells types of hematologic cytopenia.
Different symptoms and signs often from case to case, it is possible that the onset of the disease suddenly increase heat or for months or years in the form of bouts of pain joints and a feeling of fatigue arthralgias and malaise, may be a disease in its infancy in the form of headache or seizures, or mental disorder psychoses .
He spoke to the symptoms of injury to any member of the body may also occur at intervals Tfaqmat periodic exacerbations - flares.
Symptoms and signs of special joints
Which will be between the pain intermittent intermittent arthralgias to acute inflammation joints multiple acute polyarthritis occurs in 90 percent of the cases, was preceded by symptoms and signs of other symptoms of the disease several years and are most of the injuries the joints is destroyed or distorted for the detailed nondestructive and nondeforming, but with the long-term illness the joints fingers distortions that may arise.
Signs and symptoms of the skin especially
Which types:
Systemic lupus erythematosus injuries severeThis type causes a rash on the cheeks through the nose in the form of bed and be rash red and pink color malar butterfly erythema.
Injuries and systemic lupus erythematosus under severeIt causes skin rashes surface and dry circular ring-shaped on both sides of the body symmetrical, which can appear anywhere in the body, but usually appears on the back, chest, and this kind does not leave fibrosis scars in places that it infects and is accompanied usually symptoms of other systemic meaningful.
Injuries and chronic systemic lupus chronic lupus erythematosusIt is usually called lupus roundThis type is most common, and causes a rash on the form of tablets like the currency coin shaped and are usually on the cheeks and nose, but may occur upper back or on the neck or on the back of the hands or on the lips or the scalp and the rash is red and has scales scaly and this type leaves a lasting impact permanent scars, and may cause permanent loss of hair the place of infection permanent hair loss, and when it hit the scalp and the emergence of areas of hair loss and infected Baltalbh in spots or alopecia General generalized or focal during disease activity, and may cause such ulcers and crusts when you hit the lips. There are other types of skin lesions, a rare species.
And must be infected with any of these species not to be subjected to the sun and wear sunscreen and that's where the sun over these situations worse, and must put Paints and sunscreen before exposure to the sun half an hour if necessary.
And cause inflammation of the tissues under the skin and there is a nodular lesions and cause inflammation of blood vessels, redness of the skin mottled mottled erythema Evin, fingers, periungual erythema around the nails occur as clusters of blood under the skin purpura & petechiae.
Signs and symptoms of heart and lungs
And include the inflammation of repeated membrane around the lungs recurrent pleurisy with an infiltrate of pleural effusion or lack of it has complications such as bleeding from the lungs, pulmonary hemorrhage or clots artery pulmonary pulmonary emboli or high pressure artery pulmonary pulmonary hypertension or contraction of the lungs or the so-called lung syndrome shrinking shrinking lung syndrome . The signs and symptoms of heart disease include inflammation of the membrane about around the heart pericarditis are the most common complication and leak around the heart and pericardial effusion, myocarditis, myocarditis.
Symptoms and signs of lymph nodes and spleen
The inflammation occurs in lymph nodes generalized adenopathy is common, especially in children and young adults, young adults and people with dark skin blacks and enlarged spleen occurs in 10 percent of the infected cases lupus erythematosus.
Signs and symptoms related to nervous system
Arise due to the infection of any part of the central nervous system or peripheral central or peripheral nervous or membranes around the brain meninges, and the most common symptoms of small defects in the perception mild cognitive impairment or headache or changes in personality personality changes or lack of arteries brain ischemic stroke or bleeding under the class site of the meninges surrounding the brain subarachnoid hemorrhage or seizures or convulsions, psychoses or mental disorder organic brain syndrome organic brain syndrome or disorder Palmkhikh cerebellar dysfunction or inflammation of the membrane sterile meningitis aseptic meningitis or peripheral nerve disorders or peripheral neuropathies browser myelitis transverse myelitis.
Signs and symptoms especially the kidneys
It may appear at any time, have them show symptoms of the disease without appearing in any other member, and may be benign or severe, and symptoms include the presence of protein in urine proteinuria and red blood cells, white and high blood pressure with fluids collect between the cells of body tissues. May result in kidney failure kidney injury.
Symptoms and signs of blood
Include a shortage of red blood cell count any kinds of red, white and platelets.
Symptoms related to digestive system
There may be abdominal pain, nausea or vomiting, and arises as a result of affected bowel movement or inflammation of blood vessels.
Impact of the disease on pregnancy
May cause fetal loss in early pregnancy or in the end, however, pregnancy and birth be successful in cases where the disease is latent and active throughout pregnancy.
TestsIncluding:
Work analysis of blood for the detection of antibodies to the nucleus of cells of the body antinuclear antibodies - ANA
Work analysis of blood for the detection of antibodies to the cell means anticytoplasmic antibodies
The work of counting the white blood cells, red and platelets, which fall in the incidence of lupus
The work of Paul's analysis revealed the presence of protein in urine proteinuria and red blood cells and cells Sididip
DiagnosisBe diagnosed with the disease symptoms, signs and medical examinations. There are standards for doctors to diagnose a clinical and laboratory criteria for clinical and serologic criteria.
Treatment
You should avoid sun exposure and the development of paints to prevent the impact.
Give aspirin to prevent clotting.
Given antimalarials such as chloroquine, hydroxychloroquine hydroxy compound as a treatment reduces the inflammation of the tissues arising as a result of the disease.
Given steroids and corticosteroids and immunosuppressants immunosuppression, especially in periods of disease activity and severity of severe ongoing active disease.
A chronic disease that affects multiple organ multisystem, and is characterized by the existence of periods of activity, exacerbations and periods of latency remissions, and most of the injuries it is among women aged 15 to 45 years ie in the period fertility child bearing age, where the ratio between them from 70 to 90 percent of the total injuries disease, and disease can affect all ages, including newborn neonates.
PathophysiologyEstablished disease as a result response is normal or abnormal environmental factors (such as exposure to UV ultra-violet rays - and contained within the rays of the sun and in the light rays emitted from the light industrial - and such as exposure to infection, or taking certain medications) in people who have a genetic predisposition, As a result of this response consists of antibodies autoimmune diseases attack the body's tissues and inflammation occur by inflamation or damage to vehicles and damage immune immune complexes are deposited in blood vessels and organs of the body.
Symptoms and signsSince the disease affects multiple body organs, the symptoms and signs are numerous and vary from case to case, including:
Symptoms and signs of disease prevalent
It is joint pain and inflammation arthralgias and arthritis, and rash face and skin malar and other skin rashes and inflammation of the membranes around the lungs, heart, pleuritis or pericarditis also include the incidence of kidney and central nervous system renal and CNS involvement, as well as a decrease in the number of blood cells types of hematologic cytopenia.
Different symptoms and signs often from case to case, it is possible that the onset of the disease suddenly increase heat or for months or years in the form of bouts of pain joints and a feeling of fatigue arthralgias and malaise, may be a disease in its infancy in the form of headache or seizures, or mental disorder psychoses .
He spoke to the symptoms of injury to any member of the body may also occur at intervals Tfaqmat periodic exacerbations - flares.
Symptoms and signs of special joints
Which will be between the pain intermittent intermittent arthralgias to acute inflammation joints multiple acute polyarthritis occurs in 90 percent of the cases, was preceded by symptoms and signs of other symptoms of the disease several years and are most of the injuries the joints is destroyed or distorted for the detailed nondestructive and nondeforming, but with the long-term illness the joints fingers distortions that may arise.
Signs and symptoms of the skin especially
Which types:
Systemic lupus erythematosus injuries severeThis type causes a rash on the cheeks through the nose in the form of bed and be rash red and pink color malar butterfly erythema.
Injuries and systemic lupus erythematosus under severeIt causes skin rashes surface and dry circular ring-shaped on both sides of the body symmetrical, which can appear anywhere in the body, but usually appears on the back, chest, and this kind does not leave fibrosis scars in places that it infects and is accompanied usually symptoms of other systemic meaningful.
Injuries and chronic systemic lupus chronic lupus erythematosusIt is usually called lupus roundThis type is most common, and causes a rash on the form of tablets like the currency coin shaped and are usually on the cheeks and nose, but may occur upper back or on the neck or on the back of the hands or on the lips or the scalp and the rash is red and has scales scaly and this type leaves a lasting impact permanent scars, and may cause permanent loss of hair the place of infection permanent hair loss, and when it hit the scalp and the emergence of areas of hair loss and infected Baltalbh in spots or alopecia General generalized or focal during disease activity, and may cause such ulcers and crusts when you hit the lips. There are other types of skin lesions, a rare species.
And must be infected with any of these species not to be subjected to the sun and wear sunscreen and that's where the sun over these situations worse, and must put Paints and sunscreen before exposure to the sun half an hour if necessary.
And cause inflammation of the tissues under the skin and there is a nodular lesions and cause inflammation of blood vessels, redness of the skin mottled mottled erythema Evin, fingers, periungual erythema around the nails occur as clusters of blood under the skin purpura & petechiae.
Signs and symptoms of heart and lungs
And include the inflammation of repeated membrane around the lungs recurrent pleurisy with an infiltrate of pleural effusion or lack of it has complications such as bleeding from the lungs, pulmonary hemorrhage or clots artery pulmonary pulmonary emboli or high pressure artery pulmonary pulmonary hypertension or contraction of the lungs or the so-called lung syndrome shrinking shrinking lung syndrome . The signs and symptoms of heart disease include inflammation of the membrane about around the heart pericarditis are the most common complication and leak around the heart and pericardial effusion, myocarditis, myocarditis.
Symptoms and signs of lymph nodes and spleen
The inflammation occurs in lymph nodes generalized adenopathy is common, especially in children and young adults, young adults and people with dark skin blacks and enlarged spleen occurs in 10 percent of the infected cases lupus erythematosus.
Signs and symptoms related to nervous system
Arise due to the infection of any part of the central nervous system or peripheral central or peripheral nervous or membranes around the brain meninges, and the most common symptoms of small defects in the perception mild cognitive impairment or headache or changes in personality personality changes or lack of arteries brain ischemic stroke or bleeding under the class site of the meninges surrounding the brain subarachnoid hemorrhage or seizures or convulsions, psychoses or mental disorder organic brain syndrome organic brain syndrome or disorder Palmkhikh cerebellar dysfunction or inflammation of the membrane sterile meningitis aseptic meningitis or peripheral nerve disorders or peripheral neuropathies browser myelitis transverse myelitis.
Signs and symptoms especially the kidneys
It may appear at any time, have them show symptoms of the disease without appearing in any other member, and may be benign or severe, and symptoms include the presence of protein in urine proteinuria and red blood cells, white and high blood pressure with fluids collect between the cells of body tissues. May result in kidney failure kidney injury.
Symptoms and signs of blood
Include a shortage of red blood cell count any kinds of red, white and platelets.
Symptoms related to digestive system
There may be abdominal pain, nausea or vomiting, and arises as a result of affected bowel movement or inflammation of blood vessels.
Impact of the disease on pregnancy
May cause fetal loss in early pregnancy or in the end, however, pregnancy and birth be successful in cases where the disease is latent and active throughout pregnancy.
TestsIncluding:
Work analysis of blood for the detection of antibodies to the nucleus of cells of the body antinuclear antibodies - ANA
Work analysis of blood for the detection of antibodies to the cell means anticytoplasmic antibodies
The work of counting the white blood cells, red and platelets, which fall in the incidence of lupus
The work of Paul's analysis revealed the presence of protein in urine proteinuria and red blood cells and cells Sididip
DiagnosisBe diagnosed with the disease symptoms, signs and medical examinations. There are standards for doctors to diagnose a clinical and laboratory criteria for clinical and serologic criteria.
Treatment
You should avoid sun exposure and the development of paints to prevent the impact.
Give aspirin to prevent clotting.
Given antimalarials such as chloroquine, hydroxychloroquine hydroxy compound as a treatment reduces the inflammation of the tissues arising as a result of the disease.
Given steroids and corticosteroids and immunosuppressants immunosuppression, especially in periods of disease activity and severity of severe ongoing active disease.
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